Preventive Dermatology by Robert Norman
Author:Robert Norman
Language: eng
Format: epub
Publisher: Springer London, London
Azathioprine
Azathioprine at 1–3 mg/kg body weight has some tradition as off-label therapy for recalcitrant AE.56 The onset of action is rather slow. Myelosuppression, hepatotoxicity, and induction of skin malignancies, among others, are relevant side effects. Azathioprine is metabolized by the thiopurine methyltransferase. Around 11.5% of the population have a reduced or no activity in this enzyme caused mostly by three mutations.99 Since this enzyme deficiency causes most toxicities, enzymatic or genetic testing must be performed before starting this therapy.99
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